H2N2V1, Main, Exploration, bibRecord, 002876

Investigation of recombinants of human influenza and fowl plague viruses.

Identifieur interne : 002876 ( Main/Exploration ); précédent : 002875; suivant : 002877

Investigation of recombinants of human influenza and fowl plague viruses.

Auteurs : Y. Ghendon ; A. Klimov ; O. Blagoveshenskaya ; D. Genkina

Source :

The Journal of general virology [ 0022-1317 ] ; 1979.

RBID : pubmed:479841

Descripteurs français

KwdFr :
- ARN viral (analyse), Animaux, Embryon de poulet, Peptides (analyse), Protéines virales (analyse), Recombinaison génétique, Réplication virale, Virus de la grippe A (analyse), Virus de la grippe A (génétique).
MESH :
- analyse : ARN viral, Peptides, Protéines virales, Virus de la grippe A.
- génétique : Virus de la grippe A.
- Animaux, Embryon de poulet, Recombinaison génétique, Réplication virale.

English descriptors

KwdEn :
- Animals, Chick Embryo, Influenza A virus (analysis), Influenza A virus (genetics), Peptides (analysis), RNA, Viral (analysis), Recombination, Genetic, Viral Proteins (analysis), Virus Replication.
MESH :
- chemical , analysis : Peptides, RNA, Viral, Viral Proteins.
- analysis : Influenza A virus.
- genetics : Influenza A virus.
- Animals, Chick Embryo, Recombination, Genetic, Virus Replication.

Abstract

Recombinants of human influenza type A viruses, A/Krasnodar/101/1959 (H2N2) or A/Habarovsk/15/1976 (H3N2), and fowl plague virus (FPV), strain Weybridge (Hav1Neq1) were obtained. The genome of the recombinant obtained by recombination of influenza A/Habarovsk/15/1976 virus and FPV contained the genes 4 (HA) and 6 (NA) derived from the influenza A/Habarovsk virus and all the other genes [1, 2, 3, 5 (NP), 7 (M), 8 (NS)] from FPV. The genome of the recombinant of A/Krasnodar/101/1959 virus and FPV contained the genes 2, 4 (HA) and 6 (NA) derived from influenza A/Krasnodar virus and all the other genes [1, 3, 5, (NP), 7 (M), 8 (NS)] from FPV. The recombinants, like FPV, gave high virus yields in chick embryos and could multiply at high temperatures (40 and 42 degrees C), but, like human influenza viruses, were non-pathogenic for chickens and did not replicate in chick embryo fibroblast culture, but did replicate in a human conjunctiva cell line, clone 1-5C-4. The virion transcriptase of the recombinants, in a number of properties determined in vitro, was similar to FPV transcriptase but not to the human influenza virus enzyme.

DOI: 10.1099/0022-1317-43-1-183
PubMed: 479841

Affiliations:

Le document en format XML

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<author><name sortKey="Klimov, A" sort="Klimov, A" uniqKey="Klimov A" first="A" last="Klimov">A. Klimov</name>
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<author><name sortKey="Blagoveshenskaya, O" sort="Blagoveshenskaya, O" uniqKey="Blagoveshenskaya O" first="O" last="Blagoveshenskaya">O. Blagoveshenskaya</name>
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<author><name sortKey="Klimov, A" sort="Klimov, A" uniqKey="Klimov A" first="A" last="Klimov">A. Klimov</name>
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<author><name sortKey="Blagoveshenskaya, O" sort="Blagoveshenskaya, O" uniqKey="Blagoveshenskaya O" first="O" last="Blagoveshenskaya">O. Blagoveshenskaya</name>
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<series><title level="j">The Journal of general virology</title>
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<term>Chick Embryo</term>
<term>Influenza A virus (analysis)</term>
<term>Influenza A virus (genetics)</term>
<term>Peptides (analysis)</term>
<term>RNA, Viral (analysis)</term>
<term>Recombination, Genetic</term>
<term>Viral Proteins (analysis)</term>
<term>Virus Replication</term>
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<term>Animaux</term>
<term>Embryon de poulet</term>
<term>Peptides (analyse)</term>
<term>Protéines virales (analyse)</term>
<term>Recombinaison génétique</term>
<term>Réplication virale</term>
<term>Virus de la grippe A (analyse)</term>
<term>Virus de la grippe A (génétique)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Peptides</term>
<term>RNA, Viral</term>
<term>Viral Proteins</term>
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<term>Peptides</term>
<term>Protéines virales</term>
<term>Virus de la grippe A</term>
</keywords>
<keywords scheme="MESH" qualifier="analysis" xml:lang="en"><term>Influenza A virus</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Influenza A virus</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Virus de la grippe A</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Chick Embryo</term>
<term>Recombination, Genetic</term>
<term>Virus Replication</term>
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<front><div type="abstract" xml:lang="en">Recombinants of human influenza type A viruses, A/Krasnodar/101/1959 (H2N2) or A/Habarovsk/15/1976 (H3N2), and fowl plague virus (FPV), strain Weybridge (Hav1Neq1) were obtained. The genome of the recombinant obtained by recombination of influenza A/Habarovsk/15/1976 virus and FPV contained the genes 4 (HA) and 6 (NA) derived from the influenza A/Habarovsk virus and all the other genes [1, 2, 3, 5 (NP), 7 (M), 8 (NS)] from FPV. The genome of the recombinant of A/Krasnodar/101/1959 virus and FPV contained the genes 2, 4 (HA) and 6 (NA) derived from influenza A/Krasnodar virus and all the other genes [1, 3, 5, (NP), 7 (M), 8 (NS)] from FPV. The recombinants, like FPV, gave high virus yields in chick embryos and could multiply at high temperatures (40 and 42 degrees C), but, like human influenza viruses, were non-pathogenic for chickens and did not replicate in chick embryo fibroblast culture, but did replicate in a human conjunctiva cell line, clone 1-5C-4. The virion transcriptase of the recombinants, in a number of properties determined in vitro, was similar to FPV transcriptase but not to the human influenza virus enzyme.</div>
</front>
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<tree><noCountry><name sortKey="Blagoveshenskaya, O" sort="Blagoveshenskaya, O" uniqKey="Blagoveshenskaya O" first="O" last="Blagoveshenskaya">O. Blagoveshenskaya</name>
<name sortKey="Genkina, D" sort="Genkina, D" uniqKey="Genkina D" first="D" last="Genkina">D. Genkina</name>
<name sortKey="Ghendon, Y" sort="Ghendon, Y" uniqKey="Ghendon Y" first="Y" last="Ghendon">Y. Ghendon</name>
<name sortKey="Klimov, A" sort="Klimov, A" uniqKey="Klimov A" first="A" last="Klimov">A. Klimov</name>
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Serveur d'exploration H2N2

Investigation of recombinants of human influenza and fowl plague viruses.

Investigation of recombinants of human influenza and fowl plague viruses.

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

	Serveur d'exploration H2N2
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